DOK1 Antibody 0.1mg from Prosci
Code Prosci-1107-01
Price
AU$350.00 +GST
Applications
E, WB, ICC
Clonality
pAb
Reactivity
H
Availability
Order today and receive it by Fri, 8 Jun 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com , Fax: 03 8648 5841 OR
Qty:
Add to Cart
Product Type
Antibodies - Primary Antibody
Double click on above image to view full picture
Description
Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP). p62dok represents a new family with very recently identified p56dok.
Other Name
DOK1 (CT), DOK1
Application Notes
DOK1 antibody can be used for detection of DOK1 expression by Western blot at 0.5 - 1 μg/ml. A 62 kDa band should be detected.
Immunogen
Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.
Raised In Rabbit
Purity
Affinity chromatography purified via peptide column
Data Sheet
Click to download Data Sheet
Storage Buffer
Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions
DOK1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References
Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997;88:197-204.
