CXCR4 Antibody - Antibodies

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CXCR4 Antibody 100 µg from Biovision
Code	BIO-5224-100	Price	AU$265.00+GST
Applications	WB	Clonality	Polyclonal
Reactivity	Human, Mouse	Availability	Order today and receive it by Fri, 17 Feb 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody
Description	Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The α-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.
Other Name	chemokine (C-X-C motif) receptor 4, CXC chemokine receptor 4, CXC chemokine receptor -4, CXC chemokine receptor
Application Notes	Western blot analysis (0.5-4 µg/ml), immunoprecipitation, and immunocytochemistry. However, the optimal conditions should be determined individually. A 43 kDa band should be detected. HeLa cell lysate can be used as a positive control.
Immunogen	Synthetic peptide mapping to the N-terminus of human CXCR4
Raised In	Rabbit
Isotype	Rabbit IgG
Form	Colorless liquid
Purity	Affinity Purified Antibody
Supplier's Link	Check Supplier Link
Storage Buffer	100 µg (0.5 mg/ml) peptide affinity purified rabbit anti-CXCR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Storage Instructions

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Customer’s feedback:

I have moved over to westmead millennium institute this year. I've recently used an adiponectin ELISA from you guys that worked pretty well - you may want to change your product insert to suggest a 1:2500 dilution for mouse plasma for this assay to get right in the middle of the standard curve. I am keen on using more of the adiponectin ELISAs - can you give me a better price for this product for multiple orders?
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