CCR3 Antibody - Antibodies

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CCR3 Antibody 0.1mg from Prosci
Code	Prosci-1109-01	Price	AU$295.00+GST
Applications	E, WB	Clonality	pAb
Reactivity	H, M, R	Availability	Order today and receive it by Fri, 8 Jun 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody		Double click on above image to view full picture
Description	Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS. High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS. Protein GI No.: 30581170 Protein Accession No.: NP_847899 Blocking peptide: Cat. No. 1109P - CCR3 Peptide Positive Controls: Cat. No. 1306 - Human Spleen Tissue Lysate Note: other product sizes available
Other Name	CCR3 (NT), CC chemokine receptor 3, eosinophil eotaxin receptor
Application Notes	CCR3 antibody can be used for the detection of CCR3 by Western blot at 1 - 2 μg/ml.
Immunogen	Antibody was raised against a 14 amino acid peptide from near the amino terminus of human CCR3.
Raised In	Rabbit
Purity	Immunoaffinity purified IgG
Data Sheet	Click to download Data Sheet
Storage Buffer	Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions	CCR3 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References	Feng Y, Broder CC, Kennedy PE, et al. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272:872-7. Deng H, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996; 381:661-6. Choe H, Farzan M, Sun Y, et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996; 85:1135-48. He J, Chen Y, Farzan M, et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 1997; 385:645-9.

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