Trail Antibody - Antibodies

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Trail Antibody 0.1mg from Prosci
Code	Prosci-1113-01	Price	AU$350.00+GST
Applications	E, WB, IHC	Clonality	pAb
Reactivity	H	Availability	Order today and receive it by Fri, 24 Feb 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody		Double click on above image to view full picture
Description	Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand)1,TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kappaB activation in many tissues and cells. Protein GI No.: 4507593 Protein Accession No.: NP_003801 Blocking peptide: Cat. No. 1113P - Trail Peptide Positive Controls: Cat. No. 1201 - HeLa Cell Lysate Cat. No. 1303 - Human Brain Tissue Lysate Note: other product sizes available
Other Name	Trail (CT), Apo-2L
Application Notes	TRAIL antibody can be used for detection of TRAIL by Western blot at 1 μg/ml dilution.
Immunogen	Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human TRAIL.
Raised In	Rabbit
Purity	Ion exchange chromatography purified
Data Sheet	Click to download Data Sheet
Storage Buffer	Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions	Trail antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References	Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-682 Pitti RM; Marsters SA; Ruppert S; Donahue CJ; Moore A; Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996;271:12687-90 Pan G; O'Rourke K; Chinnaiyan AM; O'Rourke K; Gentz R; Ebner R; Ni J; Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113 Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 1997;7:831-836

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