STAT1 alpha Antibody - Antibodies

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STAT1 alpha Antibody 0.1mg from Prosci
Code	Prosci-1021-01	Price	AU$350.00+GST
Applications	E, WB, ICC, IP	Clonality	pAb
Reactivity	H, M, R	Availability	Order today and receive it by Fri, 24 Feb 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody		Double click on above image to view full picture
Description	STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-alpha, IFN-beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1alpha and the 84 kDa STAT1beta which are encoded by the same gene with splicing variant. Protein GI No.: 6274552 Protein Accession No.: NP_009330 Blocking peptide: Cat. No. 1021P - STAT1a Peptide Positive Controls: Cat. No. 1201 - HeLa Cell Lysate Cat. No. 1205 - Jurkat Whole Cell Lysate Cat. No. 1202 - A431 Cell Lysate Cat. No. 1204 - K562 Cell Lysate Note: other product sizes available
Other Name	STAT1 alpha (CT), STAT1 alpha, STAT1a
Application Notes	STAT1 alpha antibody can be used for Western blot at 1:1000 to 1:2000 and for immunoprecipitation at 2 to 4 ug per sample. A 91 kDa band can be detected. No reaction to the 84 kDa STAT1a.
Immunogen	Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human STAT1 alpha. The sequences differ from the murine corresponding sequences by four amino acids.
Raised In	Rabbit
Purity	Antibody is DEAE purified
Data Sheet	Click to download Data Sheet
Storage Buffer	Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions	STAT1 alpha antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References	Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 1998;16:293-322 Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995;64:621-51 Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-5 Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc Natl Acad Sci USA 1992;89:7836 (RD1299)

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