RAIDD Antibody - Antibodies

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RAIDD Antibody 0.1mg from Prosci
Code	Prosci-1115-01	Price	AU$350.00+GST
Applications	E, WB, ICC	Clonality	pAb
Reactivity	H	Availability	Order today and receive it by Fri, 24 Feb 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody		Double click on above image to view full picture
Description	Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals1,3. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1. Protein GI No.: 1785557 Protein Accession No.: AAB42217 Blocking peptide: Cat. No. 1115P - RAIDD Peptide Positive Controls: Cat. No. 1201 - HeLa Cell Lysate Cat. No. 1204 - K562 Whole Cell Lysate Note: other product sizes available
Other Name	RAIDD (IN), CRADD
Application Notes	RAIDD antibody can be used for detection of RAIDD by Western blot at 1:500 to 1:1000 dilution. A 22 kDa band should be detected.
Immunogen	Antibody was raised against a peptide corresponding to amino acids 99 to 117 of human RAIDD.
Raised In	Rabbit
Purity	Affinity chromatography purified via peptide column
Data Sheet	Click to download Data Sheet
Storage Buffer	Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions	RAIDD antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References	Duan H, Dixit VM. RAIDD is a new 'death' adaptor molecule. Nature 1997;385:86-89 Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G, Fernandes-Alnemri T, Alnemri ES. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res 1997 57:615-619 Hofmann K, Bucher P, Tschopp J. The CARD domain: a new apoptotic signalling motif. Trends Biochem Sci 1997;22:155-156 (RD1299)

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