CCR5 Antibody - Antibodies

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CCR5 Antibody 0.1mg from Prosci
Code	Prosci-1112-01	Price	AU$350.00+GST
Applications	E, WB, IHC	Clonality	pAb
Reactivity	H	Availability	Order today and receive it by Fri, 24 Feb 2012
Order: Tel: 1300 543 373, Email: info@liferesearch.com, Fax: 03 8648 5841 OR			Qty:
Product Type	Antibodies - Primary Antibody		Double click on above image to view full picture
Description	Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes. Protein GI No.: 2104520 Protein Accession No.: AAB57793 Blocking peptide: Cat. No. 1112P - CCR5 Peptide Positive Controls: Cat. No. 1208 - THP-1 Cell Lysate Cat. No. 1369 - Human Lymph Node Tissue Lysate Note: other product sizes available
Other Name	CCR5 (NT), CCR5
Application Notes	CCR5 antibody can be used for Western blot at 1:1000 to 1:2000 dilution. An approximate 40 kDa band can be detected. CCR5 antibody can also detect CCR5 by immunohistochemistry at 20 μg/ml.
Immunogen	Antibody was raised against a peptide corresponding to amino acids 6 to 20 of human CCR5.
Raised In	Rabbit
Purity	Antibody is DEAE purified
Data Sheet	Click to download Data Sheet
Storage Buffer	Antibody is supplied in PBS containing 0.02% sodium azide.
Storage Instructions	CCR5 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References	Dimitrov, DS. Cell 1997;91:721-30 Littman, DR. Cell 1998;93:677-80 Deng, H, et al. Nature 1996;381:661-6 Dragic, T, et al. Nature 1996;381:667-73

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